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 首頁  國家衛(wèi)健委功能性腦疾病診治重點實驗室  人員隊伍  博士后 詳細(xì)

國家衛(wèi)健委功能性腦疾病診治重點實驗室

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研究方向(含承擔(dān)課題) 著作論文

導(dǎo)航菜單

研究方向(含承擔(dān)課題)

致力于抑郁癥及自殺的發(fā)病機制和相關(guān)治療策略研究。通過靶向代謝組學(xué)分析等方法，篩選內(nèi)源性小分子代謝物，旨在尋找安全性較高，有助于解決抑郁癥臨床診治困境的抗抑郁天然物質(zhì)。

著作論文

1. Fan L^#, Yang L, Li X, et al. Proteomic and metabolomic characterization of amygdala in chronic social defeat stress rats [J]. Behavioural brain research, 2021, 412: 113407.

2. Teng T, Fan L^#, Yan W, et al. A diathesis-stress rat model induced suicide-implicated endophenotypes and prefrontal cortex abnormalities in the PKA and GABA receptor signaling pathways [J]. Progress in neuro-psychopharmacology & biological psychiatry, 2022, 116: 110538.

3. Wang J, Fan L^#, Teng T, et al. Adolescent male rats show altered gut microbiota composition associated with depressive-like behavior after chronic unpredictable mild stress: Differences from adult rats [J]. Journal of psychiatric research, 2024, 173: 183-9.

4. Tian T, Xu B, Qin Y, Fan L^#,et al. Clostridium butyricum miyairi 588 has preventive effects on chronic social defeat stress-induced depressive-like behaviour and modulates microglial activation in mice [J]. Biochemical and biophysical research communications, 2019, 516(2): 430-6.