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 首頁  國家衛(wèi)健委功能性腦疾病診治重點實驗室  人員隊伍  研究人員 詳細

國家衛(wèi)健委功能性腦疾病診治重點實驗室

人員隊伍 

李琦

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博士生導師

基本情況研究方向(含承擔課題) 著作論文

導航菜單

基本情況

重慶醫(yī)科大學附屬第一醫(yī)院，神經(jīng)內科主任醫(yī)師，教授，博士生導師?，F(xiàn)任中國卒中學會第二屆青年理事會常務理事、中國卒中學會醫(yī)療質量管理與促進分會第二屆委員會委員、中華醫(yī)學會神經(jīng)病學分會第八屆委員會神經(jīng)影像協(xié)作組委員、中華全國青年聯(lián)合會第十三屆委員會委員。

入選國家高層次人才特殊支持計劃（萬人計劃）青年拔尖人才、重慶市杰青、重慶市青年拔尖人才、中國科協(xié)青年人才托舉工程等；在Lancet、Annals of Neurology、Neurology、Radiology、Stroke、JNNP等雜志發(fā)表SCI論文100余篇；主持國家重點研發(fā)計劃項目課題、國自然面上項目等科研項目10余項，累計經(jīng)費971萬元；獲得重慶市科技進步二等獎1項（第一完成人），省部級科技進步一等獎4項，授權專利5項；獲得美國神經(jīng)病學會國際學者獎、中國杰出神經(jīng)內科醫(yī)師-青年醫(yī)師獎等榮譽。

研究方向(含承擔課題)

長期致力于腦血管疾病及神經(jīng)影像學研究，提出并命名了混合征、黑洞征、李琦島征三個平掃CT征象預測腦出血早期血腫擴大，被哈佛大學等學者驗證并廣泛應用于臨床，寫入美國醫(yī)學院教學資料；在國際上首次提出并命名罕見腦血管疾病“椎動脈壓迫綜合征”（Vertebral artery compression syndrome）；提出腦出血超早期治療時間窗概念，并證明超早期治療能夠改善患者預后。3篇文章被F1000收錄和推薦，研究成果寫入10部國內外指南并成為腦出血CT影像學國際標準。

著作論文

1. Li Q#, Warren AD, Qureshi AI, Morotti A, Falcone GJ, Sheth KN, Shoamanesh A, Dowlatshahi D, Viswanathan A, Goldstein JN. Ultra-Early Blood Pressure Reduction Attenuates Hematoma Growth and Improves Outcome in Intracerebral Hemorrhage. Ann Neurol. 2020 May 26, 88(2):388-395.

2. Li Q#, Zanon Zotin MC, Warren AD, Ma Y, Gurol E, Goldstein JN, Greenberg SM, Charidimou A, Raposo N, Viswanathan A. CT-Visible Convexity Subarachnoid Hemorrhage is Associated With Cortical Superficial Siderosis and Predicts Recurrent ICH. Neurology. 2021 Feb 16; 96(7):e986-e994.

3. Li Q#, Goldstein JN. Neurological Deterioration in Intracerebral Hemorrhage: Can We Predict It, and What Would We Do If We Could? J Am Heart Assoc. 2022 Aug 2;11(15):e026760.

4. Li XH, Yang WS, Shen YQ, Liu F, Xiong X, Wu QY, Xiao ZS, Yang X, Dang R, Manaenko A, Xie P, Li Q*. Analysis of Age-Dependent Transcriptomic Changes in Response to Intracerebral Hemorrhage in Mice. Front Mol Neurosci. 2022 May 23;15:908683.

5. Wang ZJ, Zhao R, Hu X, Yang WS, Deng L, Lv XN, Li ZQ, Cheng J, Pu MJ, Tang ZP, Wu GF, Zhao LB, Xie P, Li Q*. Higher Cerebral Small Vessel Disease Burden in Patients With Small Intracerebral Hemorrhage. Front Neurosci. 2022 May 12;16:888198.

6. Shen YQ, Yang WS, Xiong X, Li XH, Xiao ZS, Yu JL, Liu FY, Gui SW, Xie XF, Lv FJ, Zhao LB, Hu LB, Manaenko A, Xie P*, Li Q*. Integrated Multiomics Analysis Identifies a Novel Biomarker Associated with Prognosis in Intracerebral Hemorrhage, Oxidative Medicine and Cellular Longevity, 2021, 2021: 2510847.

7. Lv XN, Li ZQ, Deng L, Yang WS, Li YL, Huang YJ, Shen YQ, Xie XF, Li XH, Wang ZJ, Zhang ZW, Lv FJ, Luo JB, Sun SJ, Xie P, Li Q*. Early Perihematomal Edema Expansion: Definition, Significance, and Association with Outcomes after Intracerebral Hemorrhage. Oxid Med Cell Longev. 2021 Sep 12;2021:6249509.

8. Li Q#, Wang ZJ, Viswanathan A. Intracerebral hemorrhage and small vessel disease. Chin Med J (Engl). 2021 Sep 9;134(19):2287-2289.

9. Akram MJ, Zhao R, Shen X, Yang WS, Deng L, Li ZQ, Hu X, Zhao LB*, Xie P*, Li Q*. Surgical vs. Conservative Management for Lobar Intracerebral Hemorrhage, a Meta-Analysis of Randomized Controlled Trials. Front Neurol. 2022 Jan 20;12:742959.

10. Li YL, Zhao R, Zheng YN, Wei M, Li ZQ, Hu X, Li Q*, Lv FJ*. 3D island sign on computed tomography predicts early perihematomal edema expansion and poor outcome in patients with intracerebral hemorrhage. Clin Neurol Neurosurg. 2022 Sep 15;222:107443.

11. Yang WS, Shen YQ, Yang X, Li XH, Xu SH, Zhao LB, Li R, Xiong X, Bai SJ, Wu QY, Manaenko A, Li Q*, Xie P*. MicroRNA Transcriptomics Analysis Identifies Dysregulated Hedgehog Signaling Pathway in a Mouse Model of Acute Intracerebral Hemorrhage Exposed to Hyperglycemia. J Stroke Cerebrovasc Dis. 2022 Mar;31(3):106281.

12. Li YL, Lv XN, Wei X, Yang WS, Li R, Deng L, Wei M, Li Q*, Lv FJ*. Relationship Between Non-contrast Computed Tomography Imaging Markers and Perihemorrhagic Edema Growth in Intracerebral Hemorrhage. Neurocrit Care. 2021 May 3.

13. Yang WS, Shen YQ, Wei X, Zhao LB, Liu QJ, Xie XF, Zhang ZW, Deng L, Lv XN, Zhang SQ, Li XH, Li Q*, Xie P*. New Prediction Models of Functional Outcome in Acute Intracerebral Hemorrhage: The dICH Score and uICH Score. Front Neurol. 2021, 12 (536).

14. Lv XN, Deng L, Yang WS, Wei X*, Li Q*. Computed Tomography Imaging Predictors of Intracerebral Hemorrhage Expansion. Curr Neurol Neurosci Rep. 2021 Mar 12;21(5):22.

15. Li Q#, Deng L, Huang C, Zhang WY, Zou N, Cao D, Wei X, Qin XY. A Novel Scale for Assessment of Stroke Severity at Symptom Onset: Correlation With Neurological Deterioration and Outcome. Front Neurol. 2021 Jan 22;11:602839.

16. Yang WS, Zhang SQ, Shen YQ, Wei X, Zhao LB, Xie XF, Deng L, Li XH, Lv XN, Lv FJ, Dowlatshahi D, Li Q*, Xie P*. Noncontrast Computed Tomography Markers as Predictors of Revised Hematoma Expansion in Acute Intracerebral Hemorrhage. J Am Heart Assoc. 2021 Feb 2.

17. Ye F, Li J, Wang T, Lan K, Li H, Yin H, Guo T, Zhang X, Yang T, Liang J, Wu X, Li Q*, Sheng W*. Efficacy and Safety of Antiplatelet Agents for Adult Patients With Ischemic Moyamoya Disease. Front Neurol. 2021 Jan 15.

18. Li Y, Ren S, Wang L, Mao Y, Wu G*, Li Q*, Tang Z*. Is the CT Blend Sign Composed of Two Parts of Blood with Different Age? Neurocrit Care. 2021 Jan 6.

19. Deng L, Zhang YD*, Ji JW, Yang WS, Wei X, Shen YQ, Li R, Zhang SQ, Lv XN, Li XH, Tang ZP, Wu GF, Zhao LB, Xie P, Li Q*. Hematoma Ventricle Distance on Computed Tomography Predicts Poor Outcome in Intracerebral Hemorrhage. Front Neurosci. 2020 Nov 19;14:589050.

20. Yang WS, Shen YQ, Zhang XD, Zhao LB, Wei X, Xiong X, Xie XF, Li R, Deng L, 20. Li XH, Lv XN, Lv FJ, Li Q*, Xie P*. Hydrocephalus Growth: Definition, Prevalence, Association with Poor Outcome in Acute Intracerebral Hemorrhage. Neurocrit Care. 2020 Nov 10.